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Cavernous hemangioma

MedGen UID:
9184
Concept ID:
C0018920
Neoplastic Process
Synonyms: Cavernous Hemangioma; Cavernous Hemangiomas; Hemangioma, Cavernous; Hemangioma, Strawberry; Hemangiomas, Cavernous; Hemangiomas, Strawberry; Strawberry Hemangioma; Strawberry Hemangiomas
SNOMED CT: Cavernous hemangioma (416824008); Cavernous nevus (416824008); Strawberry hemangioma (56975005); Cavernous hemangioma (33377007)
 
HPO: HP:0001048
Monarch Initiative: MONDO:0003155

Definition

The presence of a cavernous hemangioma. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma. [from HPO]

Conditions with this feature

Cardio-facio-cutaneous syndrome
MedGen UID:
266149
Concept ID:
C1275081
Disease or Syndrome
Cardiofaciocutaneous (CFC) syndrome is characterized by cardiac abnormalities (pulmonic stenosis and other valve dysplasias, septal defects, hypertrophic cardiomyopathy, rhythm disturbances), distinctive craniofacial appearance, and cutaneous abnormalities (including xerosis, hyperkeratosis, ichthyosis, keratosis pilaris, ulerythema ophryogenes, eczema, pigmented moles, hemangiomas, and palmoplantar hyperkeratosis). The hair is typically sparse, curly, fine or thick, woolly or brittle; eyelashes and eyebrows may be absent or sparse. Nails may be dystrophic or fast growing. Some form of neurologic and/or cognitive delay (ranging from mild to severe) is seen in all affected individuals. Neoplasia, mostly acute lymphoblastic leukemia, has been reported in some individuals.
Hemangiomas of small intestine
MedGen UID:
331098
Concept ID:
C1841654
Neoplastic Process
A hemangioma that involves the small intestine.
Mucolipidosis type II
MedGen UID:
435914
Concept ID:
C2673377
Disease or Syndrome
GNPTAB-related disorders comprise the phenotypes mucolipidosis II (ML II) and mucolipidosis IIIa/ß (ML IIIa/ß), and phenotypes intermediate between ML II and ML IIIa/ß. ML II is evident at birth and slowly progressive; death most often occurs in early childhood. Orthopedic abnormalities present at birth may include thoracic deformity, kyphosis, clubfeet, deformed long bones, and/or dislocation of the hip(s). Growth often ceases in the second year of life; contractures develop in all large joints. The skin is thickened, facial features are coarse, and gingiva are hypertrophic. All children have cardiac involvement, most commonly thickening and insufficiency of the mitral valve and, less frequently, the aortic valve. Progressive mucosal thickening narrows the airways, and gradual stiffening of the thoracic cage contributes to respiratory insufficiency, the most common cause of death. ML IIIa/ß becomes evident at about age three years with slow growth rate and short stature; joint stiffness and pain initially in the shoulders, hips, and fingers; gradual mild coarsening of facial features; and normal to mildly impaired cognitive development. Pain from osteoporosis becomes more severe during adolescence. Cardiorespiratory complications (restrictive lung disease, thickening and insufficiency of the mitral and aortic valves, left and/or right ventricular hypertrophy) are common causes of death, typically in early to middle adulthood. Phenotypes intermediate between ML II and ML IIIa/ß are characterized by physical growth in infancy that resembles that of ML II and neuromotor and speech development that resemble that of ML IIIa/ß.
Adams-Oliver syndrome 5
MedGen UID:
863407
Concept ID:
C4014970
Disease or Syndrome
Adams-Oliver syndrome (AOS) is characterized by aplasia cutis congenita (ACC) of the scalp and terminal transverse limb defects (TTLD). ACC lesions usually occur in the midline of the parietal or occipital regions, but can also occur on the abdomen or limbs. At birth, an ACC lesion may already have the appearance of a healed scar. ACC lesions less than 5 cm often involve only the skin and almost always heal over a period of months; larger lesions are more likely to involve the skull and possibly the dura, and are at greater risk for complications, which can include infection, hemorrhage, or thrombosis, and can result in death. The limb defects range from mild (unilateral or bilateral short distal phalanges) to severe (complete absence of all toes or fingers, feet or hands, or more, often resembling an amputation). The lower extremities are almost always more severely affected than the upper extremities. Additional major features frequently include cardiovascular malformations/dysfunction (23%), brain anomalies, and less frequently renal, liver, and eye anomalies.
Lymphatic malformation 13
MedGen UID:
1840915
Concept ID:
C5830279
Disease or Syndrome
Lymphatic malformation-13 (LMPHM13) is characterized by the presence of nonimmune hydrops fetalis which often resolves with age. Capillary or cavernous hemangiomas are present in most patients, as are cardiac defects, often mild (Abdelrahman et al., 2018). For a discussion of genetic heterogeneity of lymphatic malformation, see 153100.

Professional guidelines

PubMed

Yang L, Li J, Wang J
Pulmonology 2023 Sep-Oct;29(5):446-447. Epub 2023 Jan 28 doi: 10.1016/j.pulmoe.2022.12.002. PMID: 36717293
Zou X, Wang L, Xiao L, Wang S, Zhang L
Front Immunol 2022;13:975921. Epub 2022 Oct 31 doi: 10.3389/fimmu.2022.975921. PMID: 36389714Free PMC Article
Turel MK, Kiehl TR, Gentili F
Neurol India 2016 Nov-Dec;64(6):1347-1351. doi: 10.4103/0028-3886.193800. PMID: 27841223

Recent clinical studies

Etiology

Ganz JC
Prog Brain Res 2022;268(1):115-132. Epub 2022 Jan 6 doi: 10.1016/bs.pbr.2021.10.029. PMID: 35074077
Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Idiculla PS, Gurala D, Philipose J, Rajdev K, Patibandla P
Eur Neurol 2020;83(4):360-368. Epub 2020 Jul 30 doi: 10.1159/000508748. PMID: 32731220
Flemming KD
Curr Cardiol Rep 2017 Oct 18;19(12):122. doi: 10.1007/s11886-017-0931-1. PMID: 29046973
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

Diagnosis

Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Su VL, Calderwood DA
Open Biol 2020 Nov;10(11):200263. Epub 2020 Nov 25 doi: 10.1098/rsob.200263. PMID: 33234067Free PMC Article
Torres G, Kini AT, Al Othman B, Lee AG
J Neuroophthalmol 2020 Jun;40(2):262-264. doi: 10.1097/WNO.0000000000000778. PMID: 30893269
Zhu WD, Huang Q, Li XY, Chen HS, Wang ZY, Wu H
J Neurosurg 2016 Mar;124(3):639-46. Epub 2015 Sep 25 doi: 10.3171/2015.3.JNS142785. PMID: 26406793
Bloch E, Hakim J
Ophthalmology 2015 Oct;122(10):2037. doi: 10.1016/j.ophtha.2015.07.006. PMID: 26398050

Therapy

Lazzaroni F, Meessen JMTA, Sun Y, Lanfranconi S, Scola E, D'Alessandris QG, Tassi L, Carriero MR, Castori M, Marino S, Blanda A, Nicolis EB, Novelli D, Calabrese R, Agnelli NM, Bottazzi B, Leone R, Mazzola S, Besana S, Catozzi C, Nezi L, Lampugnani MG, Malinverno M, Grdseloff N, Rödel CJ, Rezai Jahromi B, Bolli N, Passamonti F, Magnusson PU, Abdelilah-Seyfried S, Dejana E, Latini R
EBioMedicine 2024 Jan;99:104914. Epub 2023 Dec 18 doi: 10.1016/j.ebiom.2023.104914. PMID: 38113759Free PMC Article
Lanfranconi S, Scola E, Meessen JMTA, Pallini R, Bertani GA, Al-Shahi Salman R, Dejana E, Latini R; Treat_CCM Investigators
Lancet Neurol 2023 Jan;22(1):35-44. Epub 2022 Nov 17 doi: 10.1016/S1474-4422(22)00409-4. PMID: 36403580
Flemming KD
Curr Cardiol Rep 2017 Oct 18;19(12):122. doi: 10.1007/s11886-017-0931-1. PMID: 29046973
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article
Rabb MF, Gagliano DA, Teske MP
Surv Ophthalmol 1988 Sep-Oct;33(2):73-96. doi: 10.1016/0039-6257(88)90160-9. PMID: 3055391

Prognosis

Chen YC, Tsai CC, Chen SJ, Wu HM, Yang HC, Chen CJ, Hu YS, Lin CJ, Guo WY, Pan DH, Chung WY, Lee CC
J Neurosurg 2023 Jun 1;138(6):1622-1629. Epub 2022 Oct 7 doi: 10.3171/2022.8.JNS221222. PMID: 37856889
Bai Y, Zhao G, Tan Y
World J Surg Oncol 2019 Dec 4;17(1):205. doi: 10.1186/s12957-019-1742-1. PMID: 31801558Free PMC Article
Goldstein HE, Solomon RA
Handb Clin Neurol 2017;143:241-247. doi: 10.1016/B978-0-444-63640-9.00023-0. PMID: 28552146
Ibáñez VM, Zamora AS, Morote SC, Crespo ML, Rodríguez EF, Soria JE
Surgery 2017 Jun;161(6):1735-1736. Epub 2016 Apr 9 doi: 10.1016/j.surg.2016.02.036. PMID: 27072991
Chabert E, Morandi X, Carney MP, Riffaud L, Louail C, Carsin-Nicol B
J Neuroradiol 1999 Dec;26(4):262-8. PMID: 10783555

Clinical prediction guides

Dao L, You Z, Lu L, Xu T, Sarkar AK, Zhu H, Liu M, Calandrelli R, Yoshida G, Lin P, Miao Y, Mierke S, Kalva S, Zhu H, Gu M, Vadivelu S, Zhong S, Huang LF, Guo Z
Cell Stem Cell 2024 Jun 6;31(6):818-833.e11. Epub 2024 May 15 doi: 10.1016/j.stem.2024.04.019. PMID: 38754427Free PMC Article
Hong T, Xiao X, Ren J, Cui B, Zong Y, Zou J, Kou Z, Jiang N, Meng G, Zeng G, Shan Y, Wu H, Chen Z, Liang J, Xiao X, Tang J, Wei Y, Ye M, Sun L, Li G, Hu P, Hui R, Zhang H, Wang Y
Brain 2021 Oct 22;144(9):2648-2658. doi: 10.1093/brain/awab117. PMID: 33729480
Missori P, Peschillo S, Ambrosone A, Martini S, Rastelli E, Mancarella C, Vigliotta M, Paolini S
Clin Neurol Neurosurg 2020 Oct;197:106167. Epub 2020 Aug 22 doi: 10.1016/j.clineuro.2020.106167. PMID: 32861039
Bai Y, Zhao G, Tan Y
World J Surg Oncol 2019 Dec 4;17(1):205. doi: 10.1186/s12957-019-1742-1. PMID: 31801558Free PMC Article
Gross BA, Du R
Expert Rev Neurother 2015;15(7):771-7. Epub 2015 Jun 22 doi: 10.1586/14737175.2015.1055323. PMID: 26098013

Recent systematic reviews

Koester SW, Rhodenhiser EG, Dabrowski SJ, Benner D, Rumalla K, Scherschinski L, Catapano JS, Graffeo CS, Srinivasan VM, Lawton MT
World Neurosurg 2023 Nov;179:222-232.e2. Epub 2023 Aug 17 doi: 10.1016/j.wneu.2023.08.036. PMID: 37595838
Zou X, Wang L, Xiao L, Wang S, Zhang L
Front Immunol 2022;13:975921. Epub 2022 Oct 31 doi: 10.3389/fimmu.2022.975921. PMID: 36389714Free PMC Article
Aziz H, Brown ZJ, Baghdadi A, Kamel IR, Pawlik TM
J Gastrointest Surg 2022 Sep;26(9):1998-2007. Epub 2022 Jun 15 doi: 10.1007/s11605-022-05382-1. PMID: 35705835
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article
Gross BA, Batjer HH, Awad IA, Bendok BR
Neurosurgery 2009 May;64(5):E805-18; discussion E818. doi: 10.1227/01.NEU.0000343668.44288.18. PMID: 19404127

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